Poorly

Query Store for SQL Server 2019 Identify and Fix Poorly Performing Queries
Query Store for SQL Server 2019 Identify and Fix Poorly Performing Queries

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<p>Apply the new Query Store feature to identify and fix poorly performing queries in SQL Server.</p> <p>Query Store is an important and recent feature in SQL Server that provides insight into the details of query execution and how that execution has changed over time. Query Store helps to identify queries that aren’t performing well, or that have regressed in their performance. Query Store provides detailed information such as wait stats that you need to resolve root causes, and it allows you to force the use of a known good execution plan. With SQL Server 2017 and later you can automate the correction of regressions in performance.</p> <p><em><strong>Query Store for SQL Server 2019</strong></em> helps you protect your database’s performance during upgrades of applications or version of SQL Server. The book provides fundamental information on how Query Store works and best practices for implementation and use. You will learn to run and interpret built-in reports, configure automatic plan correction, and troubleshoot queries using Query Store when needed. <em><strong>Query Store for SQL Server 2019</strong></em> helps you master Query Store and bring value to your organization through consistent query execution times and automate correction of regressions.</p> <p><strong>What You'll Learn</strong></p> <ul> <li> <p>Apply best practices in implementing Query Store on production servers</p> </li> <li> <p>Detect and correct regressions in query performance</p> </li> <li> <p>Lower the risk of performance degradation following an upgrade</p> </li> <li> <p>Use tools and techniques to get the most from Query Store</p> </li> <li> <p>Automate regression correction and other uses of Query Store</p> </li> </ul> <p><strong>Who This Book Is For</strong></p> <p>SQL Server developers and administrators responsible for query performance on SQL Server. Anyone responsible for identifying poorly performing queries will be able to use Query Store to find these queries and resolve the underlying issues.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Comics for a Strange World: A Book of Poorly Drawn Lines COMICS FOR A STRANGE WORLD
Comics for a Strange World: A Book of Poorly Drawn Lines COMICS FOR A STRANGE WORLD

楽天ブックス

COMICS FOR A STRANGE WORLD Reza Farazmand PLUME2017 Paperback English ISBN:9780735219885 洋書 Fiction & Literature(小説&文芸) Humor

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Poorly Drawn Lines Good Ideas and Amazing Stories
Poorly Drawn Lines Good Ideas and Amazing Stories

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<p>**Don’t Miss <em>Poorly Drawn Lines</em> on <em>Cake</em>, airing on FX and streaming on FX on Hulu!</p> <p>This <em>New York Times</em> bestselling collection of absurd comics is the perfect funny gift for everyone in your life.</p> <p>“Poorly Drawn Lines is the funniest comic I've read since The Far Side.”ーWil Wheaton, actor (<em>Star Trek: The Next Generation</em>; <em>The Big Bang Theory</em>)**</p> <p>Life is weird. Embrace it. A bear flies through space. A hamster suffers a breakdown. A child marvels at the wonder of nature as worms emerge from the ground to look for vodka (as they always have). Elsewhere, a garden snake is arrested by animal control and jailed for home invasion. These are common occurrences in the world of Reza Farazmand’s wildly popular webcomic, <em>Poorly Drawn Lines</em>. Traveling from deep space to alternate realities to the bottom of the ocean, this collection includes fan favorites alongside never-before-seen comics and original essays. For the first time, Farazmand shares his inimitable take on love, nature, social acceptance, and robots.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Poorly Wrapped Gifts Rising and Thriving After Infidelity
Poorly Wrapped Gifts Rising and Thriving After Infidelity

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<p><strong>Do you feel unheard, invalidated, scared, lost and alone after learning about your partner's affair?</strong></p> <p>Do you feel stuck in your grief and are afraid you will never get your spark for life back?Are you overwhelmed by non-stop triggers and feel isolated because of the thoughts, visions and intense emotions you are having?</p> <p>Having your world shatter because you have been betrayed by your partner is devastating, leaving you feeling scared, abandoned, rejected, embarrassed and out of control. Healing feels insurmountable. In this authentic and vulnerable book, the author shares her healing path after learning about her partner's affair, striving to validate your experience and affirm to you that you are not alone in your pain and grief. This author says it like it is, giving a more practical and personal approach to healing than some of the more "clinical" resources out there.</p> <p>In this book, you will:</p> <ul> <li>Learn how to handle triggers and calm your nervous system.</li> <li>Gain tools to move through your grief and get to the other side.</li> <li>Glean insight on making choices, like whether or not to stay, addressing the affair partner, shifting your mindset, trusting your intuition, and being aware of patterns that could hinder your healing.</li> <li>Learn about intimacy after the affair, trust and moving through anger to forgiveness.</li> <li>Gather tools to facilitate self-love and empowerment.</li> </ul> <p><strong>With unflinching honesty and a refreshingly personal touch, this narrative offers a roadmap through the darkness, steering you towards a place of renewed empowerment and self-discovery. Grab your copy today!</strong></p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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洋書 Paperback, Doing Poorly on Purpose: Strategies to Reverse Underachievement and Respect Student Dignity
洋書 Paperback, Doing Poorly on Purpose: Strategies to Reverse Underachievement and Respect Student Dignity

Glomarket

*** We ship internationally, so do not use a package forwarding service. We cannot ship to a package forwarding company address because of the Japanese customs regulation. If it is shipped and customs office does not let the package go, we do not make a refund. 【注意事項】 *** 特に注意してください。 *** ・個人ではない法人・団体名義での購入はできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 ・お名前にカタカナが入っている場合法人である可能性が高いため当店システムから自動保留します。カタカナで記載が必要な場合はカタカナ変わりローマ字で記載してください。 ・お名前またはご住所が法人・団体名義(XX株式会社等)、商店名などを含めている場合、または電話番号が個人のものではない場合、税関から法人名義でみなされますのでご注意ください。 ・転送サービス会社への発送もできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 *** ・注文後品切れや価格変動でキャンセルされる場合がございますので予めご了承願います。 ・当店でご購入された商品は、原則として、「個人輸入」としての取り扱いになり、すべてニュージャージからお客様のもとへ直送されます。 ・ご注文後、30営業日以内(通常2~3週間)に配送手続きをいたします。配送作業完了後、2週間程度でのお届けとなります。 ・まれに商品入荷状況や国際情勢、運送、通関事情により、お届けが2ヶ月までかかる場合がありますのでお急ぎの場合は注文をお控えください。 ・個人輸入される商品は、全てご注文者自身の「個人使用・個人消費(日本に居住する者に寄贈される物で、当該寄贈を受ける者の個人的な使用に供される場合を含みます。)」が前 提となります。第三者への譲渡・転売が法令で禁止されるもの(医薬品、医薬部外品、化粧品等を含みますが、これに限られません。)もございますのでご注意下さい。 ・関税・消費税が課税される場合があります。詳細はこちらをご確認下さい。PC販売説明文

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Mom, There's a Man in the Kitchen and He's Wearing Your Robe The Single Mom's Guide to Dating Well Without Parenting Poorly
Mom, There's a Man in the Kitchen and He's Wearing Your Robe The Single Mom's Guide to Dating Well Without Parenting Poorly

楽天Kobo電子書籍ストア

<p>Embarking on the dating scene can be a fun though sometimes daunting prospect for any single woman. But for the more than 10 million single women in the U.S. with children at home, dating is a much more complicated matter. Whether uncoupled through divorce or death, single moms face a wide range of questions: When will I be ready to date and how do I start? When-and what-should I tell the kids? What happens if I love the guy and the kids hate him? In <em>Mom, There's a Man in the Kitchen and He's Wearing Your Robe</em>, Ellie Slott Fisher, a once-widowed, once-divorced single mother of two, speaks with refreshing candor about balancing dating and parenting. Drawing upon her own experience, the stories of many other women, and the advice of family psychologists, Fisher offers encouragement, strategies, and a healthy dose of humor for the single-but-looking mom-from how to meet men in the first place to when to introduce your date to the kids, from when and where to work sex into the equation to how to talk to your dating teenagers without looking like a hypocrite. Practical, funny, and hopeful, this is the one guide single moms need before jumping into the murky waters of the dating pool.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Formulating Poorly Water Soluble Drugs
Formulating Poorly Water Soluble Drugs

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<p>This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Formulating Poorly Water Soluble Drugs
Formulating Poorly Water Soluble Drugs

楽天Kobo電子書籍ストア

<p>The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Drawn Poorly Years 6 to 10
Drawn Poorly Years 6 to 10

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<p>This book is a collection of my daily comic journal from years six through ten. A three panel comic strip is done every day that I started in October of 2005 and still continue to do. It is a mix of funny anecdotes, diary, and philosophy as I go though life, making mistakes and if I'm lucky, learn from them.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Poorly Made in China An Insider's Account of the China Production Game
Poorly Made in China An Insider's Account of the China Production Game

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<p>An insider reveals what canーand doesーgo wrong when companies shift production to China</p> <p>In this entertaining behind-the-scenes account, Paul Midler tells us all that is wrong with our effort to shift manufacturing to China. Now updated and expanded, <em>Poorly Made in China</em> reveals industry secrets, including the dangerous practice of quality fadeーthe deliberate and secret habit of Chinese manufacturers to widen profit margins through the reduction of quality inputs. U.S. importers don’t stand a chance, Midler explains, against savvy Chinese suppliers who feel they have little to lose by placing consumer safety at risk for the sake of greater profit. This is a lively and impassioned personal account, a collection of true stories, told by an American who has worked in the country for close to two decades. <em>Poorly Made in China</em> touches on a number of issues that affect us all.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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洋書 Wiley paperback Book, Poorly Made in China: An Insider's Account of the China Production Game
洋書 Wiley paperback Book, Poorly Made in China: An Insider's Account of the China Production Game

Glomarket

*** We ship internationally, so do not use a package forwarding service. We cannot ship to a package forwarding company address because of the Japanese customs regulation. If it is shipped and customs office does not let the package go, we do not make a refund. 【注意事項】 *** 特に注意してください。 *** ・個人ではない法人・団体名義での購入はできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 ・お名前にカタカナが入っている場合法人である可能性が高いため当店システムから自動保留します。カタカナで記載が必要な場合はカタカナ変わりローマ字で記載してください。 ・お名前またはご住所が法人・団体名義(XX株式会社等)、商店名などを含めている場合、または電話番号が個人のものではない場合、税関から法人名義でみなされますのでご注意ください。 ・転送サービス会社への発送もできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 *** ・注文後品切れや価格変動でキャンセルされる場合がございますので予めご了承願います。 ・当店でご購入された商品は、原則として、「個人輸入」としての取り扱いになり、すべてニュージャージからお客様のもとへ直送されます。 ・ご注文後、30営業日以内(通常2~3週間)に配送手続きをいたします。配送作業完了後、2週間程度でのお届けとなります。 ・まれに商品入荷状況や国際情勢、運送、通関事情により、お届けが2ヶ月までかかる場合がありますのでお急ぎの場合は注文をお控えください。 ・個人輸入される商品は、全てご注文者自身の「個人使用・個人消費(日本に居住する者に寄贈される物で、当該寄贈を受ける者の個人的な使用に供される場合を含みます。)」が前 提となります。第三者への譲渡・転売が法令で禁止されるもの(医薬品、医薬部外品、化粧品等を含みますが、これに限られません。)もございますのでご注意下さい。 ・関税・消費税が課税される場合があります。詳細はこちらをご確認下さい。PC販売説明文

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Hope It All Works Out! A Poorly Drawn Lines Collection
Hope It All Works Out! A Poorly Drawn Lines Collection

楽天Kobo電子書籍ストア

<p><strong>The absurd antics, good-natured sarcasm, and misguided optimism of Mouse, Bird, Turtle, and Snail are inspiring and infectious, and a reminder that sometimes the best plan is to have no plans at all. The perfect book for comic lovers of all kinds, <em>Hope It All Works Out</em> offers a deep dive into the <em>Poorly Drawn Lines</em> comics of <em>New York Times</em> bestselling author Reza Farazmand.</strong></p> <p>On the surface, the animals in <em>Poorly Drawn Lines</em> are sophisticated, decadent creatures ー Turtle sports a beret, Snail wears shades, Bird smokes cigarettes, and Mouse assumes a fighting stance when anyone challenges his emotional fragility. But lurking beneath their surface images is a surprising warmth and charming naivete that provides the perfect setup for Reza Farazmand’s unparalleled sense of humor.</p> <p>This author-curated collection of new comics and greatest hits showcases the unique and charming world of these small animals and the amusing gap between their tough guy images and animal innocence. Familiar to millions of readers of the <em>Poorly Drawn Lines</em> webcomic and FX animated series on Hulu, this book collection includes dozens of never-before-seen comics.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Dating for Dads The Single Father's Guide to Dating Well Without Parenting Poorly
Dating for Dads The Single Father's Guide to Dating Well Without Parenting Poorly

楽天Kobo電子書籍ストア

<p>Here is the first book written specifically for men who date while answering to a higher authority: their children.</p> <p>As a single father, you’re ready to begin dating again. But are your kids ready? In this much-needed guide, relationship expert Ellie Slott Fisher comes to the rescue with no-nonsense, no-judgments advice on everything from how to ask a woman out to navigating the potential minefield of overnight dates.</p> <p>Single dads are as nervous as single moms about merging their parentalresponsibilities with their social lives,but they often don’t have intimate friendships in which to share their concerns. Drawing on her own experience as a single parent, interviews and surveys she conducted with more than a hundred single fathers and their children, and the advice of family therapist Dr. Paul Halpern, Fisher gives the lowdown on a range of tricky topics, including:</p> <p>?When do I introduce my kids to the woman I’m dating?<br /> ?What if they don’t like her?<br /> ?Is it acceptable to date someone closer to my child’s age than my own?<br /> ?Are sleepovers okay when my kidsーor her kidsーare home?<br /> ?How do I give my children the reassurance they need while pursuing a social life of my own?</p> <p>Plus, how to avoid one of the biggest dating pitfalls: mistaking lust for love. From dealing with your ex-spouse to protecting your children’s inheritance, and many issues in-between, Fisher gives single fathers the tools they need to be both sexy suitors and devoted dads.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Oral Lipid-Based Formulations Enhancing the Bioavailability of Poorly Water-Soluble Drugs
Oral Lipid-Based Formulations Enhancing the Bioavailability of Poorly Water-Soluble Drugs

楽天Kobo電子書籍ストア

<p>Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Poorly Soluble Drugs Dissolution and Drug Release
Poorly Soluble Drugs Dissolution and Drug Release

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<p>This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-?-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development.</p> <p>Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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The Poorly Made and Other Things A Story Collection
The Poorly Made and Other Things A Story Collection

楽天Kobo電子書籍ストア

<p><strong>An unsettling and creepy short story collection of literary horror set in the Renfield universe from “major new talent” (R.L. Stine) Sam Rebelein, author of <em>Edenville</em>.</strong></p> <p><strong>“I hope I get to go back to Renfield County again, before too long.” ーLitHub on <em>Edenville</em></strong></p> <p>There’s something wrong in Renfield County.</p> <p>It’s in the water, the soil, the wood. But worst of all, it’s in the minds of the residents, slowly driving them mad. When Lawrence Renfield massacred his family and drew The Giant in his farmhouse with their blood, no one imagined the repercussions. At the very least, the bloodstained wood should have been set aflame, not chopped down and repurposed as furniture, d?cor, and heirlooms across the county. But that’s exactly what happened. Now regular peopleーlike you and meーare sitting on… eating with… admiring… the cursed wood and reaping the consequences.</p> <p>These are their stories.</p> <p>In “My Name Is Ellie” a young girl uncovers disturbing secrets hiding in the walls of her beloved grandmother’s home. An unassuming box, built with reclaimed wood, connects a grieving widower with his late wife’s lingering spirit in “Hector Brim.” In “Detour” a father, desperate to return home, finds himself trapped in a dizzying maze, haunted by stories of lurking monsters that live off the remains of weary travelers.</p> <p>Playing with the uncanny to explore themes of loneliness and grief, Sam Rebelein returns upstate to unravel the mysteries of Renfield. But regardless of what started the trouble, there’s one thing of which we can be certain: for those living here, the nightmare is far from over.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Comics for a Strange World A Book of Poorly Drawn Lines
Comics for a Strange World A Book of Poorly Drawn Lines

楽天Kobo電子書籍ストア

<p>**Don’t Miss <em>Poorly Drawn Lines</em> on <em>Cake</em>, airing on FX and streaming on FX on Hulu!</p> <p>Absurd comics for our absurd times, from the artist behind the wildly popular webcomic Poorly Drawn Linesーthe perfect gift for comic book fans!**</p> <p>In his follow up to the <em>New York Times</em> bestselling <em>Poorly Drawn Lines</em>, beloved webcomic artist Reza Farazmand returns with a collection of comics that hilariously skewers our modern age. <em>Comics for a Strange World</em> takes readers through time, space, and alternate realities, reuniting fans with favorite characters and presenting them with even more bizarre scenarios. A child is arrested for plagiarism. A squirrel adapts to human society by purchasing a cell phoneーand a gun. And an old man shares memories of the Internet with his granddaughter (“A vast network of millions of idiots. Together, the idiots created endless shitty ideas. It was a true renaissance of shit.”). In the world of Poorly Drawn Lines, nothing is too weird or too outlandish for parody.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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The Unofficial World Cup Album A Poorly Illustrated Incomplete History
The Unofficial World Cup Album A Poorly Illustrated Incomplete History

楽天Kobo電子書籍ストア

<p><strong>The greatest moments in sporting history in inglorious technicolour, from the ‘artists’ known as NO SCORE DRAWS</strong></p> <p><strong>‘Genuinely upsetting.’ David Squires</strong></p> <p><strong>‘Repulsively ugly.’ S?amas O'Reilly</strong></p> <p>An Unofficial World Cup Hall of Infamy, featuring the worst fouls, best goals, most questionable refereeing decisions, dodgiest barnets, mintest kits and a host of ‘Where were you when?’ moments.</p> <p>This is the first (and, let’s face it, probably only) book from the multi-untalented team behind moderately successful Twitter account @CheapPanini, bringing mild bemusement to the world through the medium of wonky hand-drawn stickers.</p> <p>You can’t fault them for effort, even if they still can’t do hands, so dive into these pages like Roy Keane into a tackle.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Nanocrystals A Universal Tool for the Formulation of Poorly Soluble Drugs
Nanocrystals A Universal Tool for the Formulation of Poorly Soluble Drugs

楽天Kobo電子書籍ストア

<p>Nanocrystals have emerged as one of the most versatile and clinically relevant platforms for the delivery of poorly soluble drugs, with several nanocrystal-based products already on the market. Produced through both “bottom-up” and “top-down” approaches, drug nanocrystals possess a large specific surface area that enhances the dissolution and absorption of hydrophobic actives, offering a powerful strategy to improve drug performance. This book presents the fundamental principles of nanocrystal technology alongside their broad applications in modern drug delivery. Chapters explore oral bioavailability enhancement, long-acting injectable therapies, topical and transdermal delivery (including microneedles), ocular and mucosal administration, pulmonary delivery, and strategies for targeting the central nervous system. Each contribution highlights both the opportunities and the challenges of applying nanocrystal formulations across therapeutic areas. Intended for drug delivery scientists in both academia and industry, this volume provides a comprehensive overview of nanocrystal research, development, and translation into innovative therapeutic solutions. By combining rigorous science with insights into clinical and commercial impact, it serves as a valuable resource for researchers, students, and professionals aiming to harness nanocrystals in addressing complex therapeutic needs.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Hope It All Works Out!: A Poorly Drawn Lines Collection HOPE IT ALL WORKS OUT
Hope It All Works Out!: A Poorly Drawn Lines Collection HOPE IT ALL WORKS OUT

楽天ブックス

HOPE IT ALL WORKS OUT Reza Farazmand ANDREWS & MCMEEL2024 Paperback English ISBN:9781524893897 洋書 Fiction & Literature(小説&文芸) Humor

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Drawn Poorly Years 11-15
Drawn Poorly Years 11-15

楽天Kobo電子書籍ストア

<p>An ongoing collection of my daily comic journal, this book covers the years 11-15. The project was started in October of 2005 to improve my drawing skills (don't know if that worked or not) and is still being produced. 610 pages black and white with soft color cover.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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洋書 Hardcover, Suzanne Bocanegra: Poorly Watched Girls
洋書 Hardcover, Suzanne Bocanegra: Poorly Watched Girls

Glomarket

*** We ship internationally, so do not use a package forwarding service. We cannot ship to a package forwarding company address because of the Japanese customs regulation. If it is shipped and customs office does not let the package go, we do not make a refund. 【注意事項】 *** 特に注意してください。 *** ・個人ではない法人・団体名義での購入はできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 ・お名前にカタカナが入っている場合法人である可能性が高いため当店システムから自動保留します。カタカナで記載が必要な場合はカタカナ変わりローマ字で記載してください。 ・お名前またはご住所が法人・団体名義(XX株式会社等)、商店名などを含めている場合、または電話番号が個人のものではない場合、税関から法人名義でみなされますのでご注意ください。 ・転送サービス会社への発送もできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 *** ・注文後品切れや価格変動でキャンセルされる場合がございますので予めご了承願います。 ・当店でご購入された商品は、原則として、「個人輸入」としての取り扱いになり、すべてニュージャージからお客様のもとへ直送されます。 ・ご注文後、30営業日以内(通常2~3週間)に配送手続きをいたします。配送作業完了後、2週間程度でのお届けとなります。 ・まれに商品入荷状況や国際情勢、運送、通関事情により、お届けが2ヶ月までかかる場合がありますのでお急ぎの場合は注文をお控えください。 ・個人輸入される商品は、全てご注文者自身の「個人使用・個人消費(日本に居住する者に寄贈される物で、当該寄贈を受ける者の個人的な使用に供される場合を含みます。)」が前 提となります。第三者への譲渡・転売が法令で禁止されるもの(医薬品、医薬部外品、化粧品等を含みますが、これに限られません。)もございますのでご注意下さい。 ・関税・消費税が課税される場合があります。詳細はこちらをご確認下さい。PC販売説明文

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Poorly Performing Staff in Schools and How to Manage Them Capability, competence and motivation
Poorly Performing Staff in Schools and How to Manage Them Capability, competence and motivation

楽天Kobo電子書籍ストア

<p>This book will help headteachers, managers and governors diagnose and tackle poor performance where it has arisen and help them to prevent poor performance in the future. The book investigates a whole range of solutions and issues and includes detailed case-studies on: * remedial action * disciplinary action * legal and moral issues * employment law * dismissals and appeals.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Drug Delivery Strategies for Poorly Water-Soluble Drugs
Drug Delivery Strategies for Poorly Water-Soluble Drugs

楽天Kobo電子書籍ストア

<p>Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of<br /> techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies.</p> <p>Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self?microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical<br /> formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues.</p> <p>Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug<br /> delivery, polymers and biomaterials.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Poorly Written Stories
Poorly Written Stories

楽天Kobo電子書籍ストア

<p>Poorly Written Stories is a collection of work written between 2000 and 2004. The stories are part of the first era of writing for B.F. Galligan that was interrupted until 2014, then again until 2023. This collection compliments Brackets as a release of B.F. Galligan's early work, all of which is offered as an insight in to the evolution of B.F. Galligan as a writer, from a time of inspired frenzy that gives all stories from this period a surreal quality. Contained in this volume is The Downcast Eyes of the Juba Goblin, which is B. F. Galligan's second novel.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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The Poorly Made and Other Things: A Story Collection POORLY MADE & OTHER THINGS
The Poorly Made and Other Things: A Story Collection POORLY MADE & OTHER THINGS

楽天ブックス

POORLY MADE & OTHER THINGS Sam Rebelein WILLIAM MORROW2025 Paperback English ISBN:9780063252295 洋書 Fiction & Literature(小説&文芸) Fiction

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洋書 Plume paperback Book, Poorly Drawn Lines: Good Ideas and Amazing Stories
洋書 Plume paperback Book, Poorly Drawn Lines: Good Ideas and Amazing Stories

Glomarket

*** We ship internationally, so do not use a package forwarding service. We cannot ship to a package forwarding company address because of the Japanese customs regulation. If it is shipped and customs office does not let the package go, we do not make a refund. 【注意事項】 *** 特に注意してください。 *** ・個人ではない法人・団体名義での購入はできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 ・お名前にカタカナが入っている場合法人である可能性が高いため当店システムから自動保留します。カタカナで記載が必要な場合はカタカナ変わりローマ字で記載してください。 ・お名前またはご住所が法人・団体名義(XX株式会社等)、商店名などを含めている場合、または電話番号が個人のものではない場合、税関から法人名義でみなされますのでご注意ください。 ・転送サービス会社への発送もできません。この場合税関で滅却されてもお客様負担になりますので御了承願います。 *** ・注文後品切れや価格変動でキャンセルされる場合がございますので予めご了承願います。 ・当店でご購入された商品は、原則として、「個人輸入」としての取り扱いになり、すべてニュージャージからお客様のもとへ直送されます。 ・ご注文後、30営業日以内(通常2~3週間)に配送手続きをいたします。配送作業完了後、2週間程度でのお届けとなります。 ・まれに商品入荷状況や国際情勢、運送、通関事情により、お届けが2ヶ月までかかる場合がありますのでお急ぎの場合は注文をお控えください。 ・個人輸入される商品は、全てご注文者自身の「個人使用・個人消費(日本に居住する者に寄贈される物で、当該寄贈を受ける者の個人的な使用に供される場合を含みます。)」が前 提となります。第三者への譲渡・転売が法令で禁止されるもの(医薬品、医薬部外品、化粧品等を含みますが、これに限られません。)もございますのでご注意下さい。 ・関税・消費税が課税される場合があります。詳細はこちらをご確認下さい。PC販売説明文

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Formulating Poorly Water Soluble Drugs
Formulating Poorly Water Soluble Drugs

楽天Kobo電子書籍ストア

<p>The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facetsand detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Poorly Understood What America Gets Wrong About Poverty
Poorly Understood What America Gets Wrong About Poverty

楽天Kobo電子書籍ストア

<p><strong>What if the idealized image of American societyーa land of opportunity that will reward hard work with economic successーis completely wrong?</strong> Few topics have as many myths, stereotypes, and misperceptions surrounding them as that of poverty in America. The poor have been badly misunderstood since the beginnings of the country, with the rhetoric only ratcheting up in recent times. Our current era of fake news, alternative facts, and media partisanship has led to a breeding ground for all types of myths and misinformation to gain traction and legitimacy. <em>Poorly Understood</em> is the first book to systematically address and confront many of the most widespread myths pertaining to poverty. Mark Robert Rank, Lawrence M. Eppard, and Heather E. Bullock powerfully demonstrate that the realities of poverty are much different than the myths; indeed in many ways they are more disturbing. The idealized image of American society is one of abundant opportunities, with hard work being rewarded by economic prosperity. But what if this picture is wrong? What if poverty is an experience that touches the majority of Americans? What if hard work does not necessarily lead to economic well-being? What if the reasons for poverty are largely beyond the control of individuals? And if all of the evidence necessary to disprove these myths has been readily available for years, why do they remain so stubbornly pervasive? These are much more disturbing realities to consider because they call into question the very core of America's identity. Armed with the latest research, <em>Poorly Understood</em> not only challenges the myths of poverty and inequality, but it explains why these myths continue to exist, providing an innovative blueprint for how the nation can move forward to effectively alleviate American poverty.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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Lucy the Poorly Puppy
Lucy the Poorly Puppy

楽天Kobo電子書籍ストア

<p>Lauren's dog Bella is about to have puppies. Lauren can't wait, even though she knows they'll all be going to new homes as soon as they're big enough. But when the puppies are born, one is so tiny Mum and Dad aren't sure it will pull through. The littlest puppy, who Lauren names Lucy, needs hand-feeding around the clock. It's going to be a lot of work, but Lauren is determined to do everything she can to save the puppy... From the best-selling author Holly Webb comes another moving animal story.</p>画面が切り替わりますので、しばらくお待ち下さい。 ※ご購入は、楽天kobo商品ページからお願いします。※切り替わらない場合は、こちら をクリックして下さい。 ※このページからは注文できません。

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